Side Effects of Cyclobenzaprine Side effects of cyclobenzaprine 5mg are similar to those of other muscle relaxants. The 5mg tablets are often preferred because in studies, the onslaught of side effects like drowsiness and dry mouth were less than those presented by 10mg tablets.
The 5mg dose can still carry with it numerous side effects, though. Common ones can include drowsiness, nausea or weakness. More serious side effects can include hallucinations, increased heart rate and seizure. If prescribed the medicine, you will receive instructions containing all of the side effects to watch out for, so make sure to read everything before starting the drug.
Talk to Your Doctor As with any medication, if your doctor prescribes you cyclobenzaprine 5mg, make sure to discuss any other medicines you are on, or any activity that you think could affect your health in conjunction with cyclobenzaprine. Before using this medication , tell your doctor or pharmacist your medical history, especially of: This drug may make you dizzy or drowsy.
Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs , nonprescription drugs, and herbal products. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation , or trouble urinating.
Drowsiness and confusion can increase the risk of falling. During pregnancy , this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk. Consult your doctor before breast-feeding. What should I know regarding pregnancy, nursing and administering Cyclobenzaprine HCL to children or the elderly?
Interactions Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction.
Avoid taking MAO inhibitors isocarboxazid , linezolid , methylene blue, moclobemide, phenelzine , procarbazine , rasagiline , safinamide, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers such as codeine, hydrocodone , alcohol, marijuana , drugs for sleep or anxiety such as alprazolam , lorazepam , zolpidem , other muscle relaxants such as carisoprodol , methocarbamol , or antihistamines such as cetirizine , diphenhydramine.
Check the labels on all your medicines such as allergy or cough -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Comparisons of Cyclobenzaprine HCl 5 mg and placebo groups in both trials established the statistically significant superiority of the 5 mg dose for all three primary endpoints at day 8 and, in the study comparing 5 and 10 mg, at day 3 or 4 as well.
A similar effect was observed with Cyclobenzaprine HCl 10 mg all endpoints. Physician-assessed secondary endpoints also showed that Cyclobenzaprine HCl 5 mg was associated with a greater reduction in palpable muscle spasm than placebo. Analysis of the data from controlled studies shows that Cyclobenzaprine HCl produces clinical improvement whether or not sedation occurs.
Indications and Usage for Cyclobenzaprine Cyclobenzaprine HCl is indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, limitation of motion, and restriction in activities of daily living. Cyclobenzaprine HCl should be used only for short periods up to two or three weeks because adequate evidence of effectiveness for more prolonged use is not available and because muscle spasm associated with acute, painful musculoskeletal conditions is generally of short duration and specific therapy for longer periods is seldom warranted.
Cyclobenzaprine HCl has not been found effective in the treatment of spasticity associated with cerebral or spinal cord disease, or in children with cerebral palsy. Contraindications Hypersensitivity to any component of this product.
Concomitant use of monoamine oxidase MAO inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving Cyclobenzaprine or structurally similar tricyclic antidepressants concomitantly with MAO inhibitor drugs.
Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure. Warnings Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with Cyclobenzaprine Hydrochloride when used in combination with other drugs, such as selective serotonin reuptake inhibitors SSRIs , serotonin norepinephrine reuptake inhibitors SNRIs , tricyclic antidepressants TCAs , tramadol, bupropion, meperidine, verapamil, or MAO inhibitors.
Serotonin syndrome symptoms may include mental status changes e. Treatment with Cyclobenzaprine Hydrochloride and any concomitant serotonergic agents should be discontinued immediately if the above reactions occur and supportive symptomatic treatment should be initiated. Cyclobenzaprine is closely related to the tricyclic antidepressants, e.
Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke. Precautions General Because of its atropine-like action, Cyclobenzaprine HCl should be used with caution in patients with a history of urinary retention, angle-closure glaucoma, increased intraocular pressure, and in patients taking anticholinergic medication.
These patients are generally more susceptible to drugs with potentially sedating effects, including Cyclobenzaprine. Cyclobenzaprine HCl should be used with caution in subjects with mild hepatic impairment starting with a 5 mg dose and titrating slowly upward. In the elderly, the frequency and severity of adverse events associated with the use of Cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, Cyclobenzaprine HCl should be initiated with a 5 mg dose and titrated slowly upward.
If concomitant treatment with Cyclobenzaprine Hydrochloride and other serotonergic drugs is clinically warranted, careful observation is advised, particularly during treatment initiation or dose increases see WARNINGS.
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